All You Want to Know About Duovir-N Medication
Duovir-N is a blend of 3 drugs commonly used to teat Human Immunodeficiency Virus (HIV) infection. It is a common clinical remedy offered in the form of film-coated tablets. The main ingredients of this product are Zidovudine, Lamivudine and Nevirapine. These medical substances have a history of being employed in the effective management of the infection with the well known HIV virus.
Use of antiretroviral nucleoside analogues alone or in combination, including stavudine and lamivudine has led to lactic acidosis/severe hepatomegaly with steatosis, including fatal cases. It happens particularly in women. Obesity and prolonged nucleoside exposure may be risk factors.
Zidovudine and lamivudine should be administered to any patient with proper care, and particularly to those who have problems for liver. Cases have also been reported in patients with unknown risk aspects. Therapy should be interrupted in any patient who develops clinical or laboratory findings indicating lactic acidosis or hepatotoxicity (which may include hepatomegaly and steatosis), even in the lack of marked amino-transferase elevations.
Caution is much needed while using Duovir-N in patients who have bone marrow compromise evidenced by granulocyte count < 1000 cells/mm3 or hemoglobin < 9.5 g/dl (see Side Effects).
You must tell your doctor if you are pregnant or planning to be pregnant. The elements of Duovir-Nsuch as lamivudine, zidovudine and nevirapine are all categorized under category C. re no adequate and well-controlled studies have been made in pregnant women. It should be used during pregnancy only if the potential benefits are more important than the potential risk.
Monitoring of Patients
Clinical chemistry tests, such as liver function tests, should be conducted earlier than initiating lead-in nevirapine therapy and at right intervals during treatment.
Overdose
Unfortunately, scientists have not yet been able to determine an effective solution against Duovir-N over-dosage. There overdose should be avoided in patients. An overdose of this medicine can cause vomiting and / or nausea. Other symptoms may include: confusion, lethargy, drowsiness, headache, grand mal seizure, etc.
Missed Dose
A missed dose should be replaced the moment the individual re-gains access to his or her pack of this antiretroviral medication. But it would be better to consult your clinical professional about it.
Duovir-Nis contra-indicated in patients who have revealed clinically essential hypersensitivity to any of the elements containing in the formulation. It also should not be used in patients who only begin therapy with nevirapine. These patients should adapt to the dosage nevirapine 200 mg o.d. while this formulation has a dosage of service nevirapine 200mg b.d.
Clinical trials have shown that a therapy course with this medication can trigger a set of adverse effects. The most common side effects during their therapy course with Duovir-Nare: dizziness, insomnia, neutropenia, cough, nasal signs, neuropathy, chills / fever, diarrhea, vomiting, anorexia, fatigue, malaise, etc. If you find any of these symptoms do not get panic, as they are usual responses of your organism. On the other hand, report all changes of this kind to your main doctor.