How Should I Take Duovir-N (Lamivudine/Zidovudine/Nevirapine)?
Duovir-N (Lamivudine/Zidovudine/Nevirapine)is wide known for treatment of an infection of a HIV as soon as patients have steady on a mode of service nevirapine a switching board on 200 mg, and revealed satisfactory tolerance capacity to nevirapine.
DOSAGE AND ADMINISTRATION
Take Duovir-N accompanied with food or at least with milk. It will help you prevent the developing of an unwanted stomach upset. An a dult can take 1 tablet of Duovir-Ntwice daily. Duovir-Nis contraindicated for use in patients who have recently started therapy with nevirapine. This is because an early lead-in dosing of 200 mg nevirapine once daily for 2 weeks is approved. Following this lead-in dose, a dose can be increase up to (maintenance dose) 200 mg nevirapine bd if the patient doesn’t experience any hypersensitivity reactions such as, rash, liver function test abnormalities.
Dosage Adjustment
Lamivudine
AsDuovir-Nis a fixed-dose combination, it can’t be used in patients calling for dosage adjustment, such as those with low body weight (<50 kg).
Zidovudine
Duovir-N should not be recommended for those patients who need dosage adjustment such as those with reduced renal function (creatinine clearance < 50 ml/min) or those experiencing dose-limiting adverse events.
Nevirapine
if patients observe severe rash or a rash along with constitutional findings,Duovir-N (Lamivudine/Zidovudine/Nevirapine)must not be used any more. Patients who observe mild to moderate rash during the 14-day lead-in period of 200 mg/day should not raise their nevirapine dose or start therapy with this medication until the rash has resolved.
If the patients observe moderate or severe liver function tests abnormalities (excluding GGT), use of this medication should be interrupted, until the liver function test altitudes have returned to normal level. Nevirapine (using Nevimune Tablets) may then be reused at 200 mg per day. The patient can raise the daily dose to 200 mg twice daily (using Duovir-N) with due caution, after complete observation. Nevirapine should be eternally ceased if moderate or severe liver function test abnormalities return.
Patients who have discontinued nevirapine dosing for more than 7 days should reuse a recommended dosing of one 200 mg Nevimune tablet daily for the first 14 days (lead-in) together with the other antiretroviral, followed by 200 mg twice daily using Duovir-N. It should be taken if you don’t find any signs of adverse reaction. A dosage of nevirapine may not be medically approved in patients with hepatic dysfunction, renal insufficiency or undergoing dialysis.
Overdoses
Lamivudine
It is unknown whether there is any remedy for an overdose of lamivudine. A patient wes reported ingesting 6 grams of lamivudine; but there were no clinical signs or symptoms noted and hematologic tests remained normal. It is not clear whether lamivudine can be got away by peritoneal dialysis or hemodialysis.
Zidovudine
Some pediatric patients and adults had reported an acute overdoses of zidovudine that is up to 50 grams. This overdose had resulted in nausea and vomiting. While there some patients who experienced headache, dizziness, drowsiness, lethargy, confusion and one report of a grand mal seizure. Hematologic changes were short-lived. Hemodialysis and peritoneal dialysis have a minor effect on the removal of zidovudine while eradication of its primary metabolite is increased.
Nevirapine
There is no known antidote for nevirapine overdose. Patients who have taken from 800 to 1800 mg per day for up to 15 days experienced events including edema, erythema nodosum, fatigue, fever, headache, imsomnia, nausea, pulmonary infiltrates, rash, vertigo, vomiting and weight decrease. All events went away after discontinuation of nevirapine.